# 6. Robustness in biological circuits¶

Design principles

• The on-delay of the C1-FFL is robust to changes in the ratio of the Hill activation constants, $$\kappa$$, in the regime when $$\kappa$$ is order one or greater.

• Exact adaptation, such as that displayed by the chemotaxis circuit in E. coli, can be achieved through integral feedback.

Techniques

• Michaelis-Menten kinetics to model enzyme dynamics.

Concepts

• Robustness.

[1]:

import numpy as np
import scipy.integrate

import biocircuits

import bokeh.io
import bokeh.plotting

import panel as pn
pn.extension()

bokeh.io.output_notebook()